MedPage Today: Antibiotics Inferior to Appendectomy for Uncomplicated Appendicitis in Kids

Dr. Shawn St. Peter

By Tara Haelle

Antibiotic management of acute uncomplicated appendicitis among children was inferior to appendectomy, a randomized non-inferiority trial showed.

For nearly 850 children with available primary outcome data, treatment failure at 12 months occurred in 34% of those who received antibiotics compared with 7% of those who underwent appendectomy, a difference of 26.7% (90% CI 22.4-30.9) that exceeded the 20% non-inferiority margin, reported Shawn St. Peter, MD, of Children's Mercy Hospital in Kansas City, Missouri, and colleagues in The Lancet.

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