Physicians Weekly: Risk Factors Linked With Reactions to Peanut OIT in Preschoolers
Specific risk factors appear to affect how strongly preschool children react to peanut oral immunotherapy (P-OIT), researchers state in a report appearing in The Journal of Allergy and Clinical Immunology Global.
“Our study identified several clinically important risk factors for grade 2 and higher reactions during P-OIT: pre-OIT grade 2+ initial reaction, allergic rhinitis, older age, and higher baseline peanut-specific IgE,” senior study author Lianne Soller, PhD, MSc, and colleagues write.
“These results highlight the need for individualized risk stratification for OIT—for example, consideration of slower buildup for patients with these risk factors,” Dr. Soller says. Grade 2 reactions to OIT peanut desensitization commonly include: mild to moderate limitation in activity, persistent hives, vomiting, and wheezing, notes Jodi Shroba, MSN, APRN, CPNP, who was not involved in the study.
To explore the links between baseline traits and reactions during preschool P-OIT, Dr. Soller and her colleagues analyzed Food Allergy Immunotherapy (FAIT) registry data from various allergy clinics.
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